Guidelines

EHTG is moving towards issuing future guidelines in a “living guidance” format, meaning that the updating of the content is a constant process as new evidence arises. The current guidelines and ongoing updates include:

Published clinical guidelines

PJS

The Management of Peutz-Jeghers Syndrome: European Hereditary Tumour Group (EHTG) Guideline.
J Clin Med. 2021 Jan 27;10(3):473. doi: 10.3390/jcm10030473

Lynch Syndrome / HNPCC

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
Br J Surg. 2020 Sep 21.

The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome. Guideline.
Genet Med. 2019 Oct;21(10):2390-2400. doi: 10.1038/s41436-019-0489-y. Epub 2019 Mar 28.

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Practice Guideline.
Gut. 2013 Jun;62(6):812-23. doi: 10.1136/gutjnl-2012-304356. Epub 2013 Feb 13.

Recommendations to improve identification of hereditary and familial colorectal cancer in Europe. Fam Cancer.
2010 Jun;9(2):109-15. doi: 10.1007/s10689-009-9291-3. Epub 2009 Sep 18.

Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). Review J Med Genet.
2007 Jun;44(6):353-62. doi: 10.1136/jmg.2007.048991. Epub 2007 Feb 27.

AMSII criteria: New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.
Gastroenterology 1999;116:1453–6

AMSI criteria: The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC).
Dis Colon Rectum 1991;34:424–5

Other HNPCC/Lynch guidelines of interest

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG).
Practice Guideline. Gut. 2020 Mar;69(3):411-444. doi: 10.1136/gutjnl-2019-319915. Epub 2019 Nov 28.

NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019.
J Natl Compr Canc Netw. 2019 Sep 1;17(9):1032-1041. doi: 10.6004/jnccn.2019.0044. PMID: 31487681.

Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability.
J Natl Cancer Inst 2004;96:261–8

FAP

Surgical management of the duodenal manifestations of familial adenomatous polyposis

Guidelines for the clinical management of familial adenomatous polyposis (FAP)

In process

  • FAP, MAP (Gabriela Moeslein, Gloria Zaffaroni, Julian Sampson)
  • Juvenile polyposis (Karl Heinimann)

* The concept of “dynamic” guidelines proceeds to shape and the Lynch syndrome Updated Guidelines have been published in BJS. Also, under the leadership of Anja Wagner and following all highest standards, the EHTG PJS guidelines have also been published and we are establishing the troops for the update of our FAP guidelines from 2008.

Contact Information

European Hereditary Tumour Group
Secretary:
Gabriele Sponholz

+49 (0)160 84 59 502
gs007@ethg.org

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