Guidelines

EHTG has a track record of expanding guidelines and practises the concept of “dynamic guidelines”. This concept means that whenever evidence has been produced in the published literature that should lead to a change of previous guidelines and is relevant for the clinical management of a syndrome, EHTG will ask for a revision of the corresponding chapter.

Current Guidelines in process

  • FAP and rare adenomatous polyposis syndromes (Coordinators: Gloria Zaffaroni and Gabriela Möslein)
  • Oligopolyposis (Coordinator: Elizabeth Half)
  • Revision and Update of the current EHTG-ESCP Guidelines for Lynch Syndrome (Giulia Martina Cavestro, Alessandro Mannucci, Gabriela Möslein)

Published clinical guidelines

PJS

The Management of Peutz-Jeghers Syndrome: European Hereditary Tumour Group (EHTG) Guideline.
J Clin Med. 2021 Jan 27;10(3):473. doi: 10.3390/jcm10030473

Lynch Syndrome / HNPCC

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender
Br J Surg. 2020 Sep 21.

The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome. Guideline.
Genet Med. 2019 Oct;21(10):2390-2400. doi: 10.1038/s41436-019-0489-y. Epub 2019 Mar 28.

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Practice Guideline.
Gut. 2013 Jun;62(6):812-23. doi: 10.1136/gutjnl-2012-304356. Epub 2013 Feb 13.

Recommendations to improve identification of hereditary and familial colorectal cancer in Europe. Fam Cancer.
2010 Jun;9(2):109-15. doi: 10.1007/s10689-009-9291-3. Epub 2009 Sep 18.

Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). Review J Med Genet.
2007 Jun;44(6):353-62. doi: 10.1136/jmg.2007.048991. Epub 2007 Feb 27.

AMSII criteria: New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.
Gastroenterology 1999;116:1453–6

AMSI criteria: The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC).
Dis Colon Rectum 1991;34:424–5

Other HNPCC/Lynch guidelines of interest

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG).
Practice Guideline. Gut. 2020 Mar;69(3):411-444. doi: 10.1136/gutjnl-2019-319915. Epub 2019 Nov 28.

NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019.
J Natl Compr Canc Netw. 2019 Sep 1;17(9):1032-1041. doi: 10.6004/jnccn.2019.0044. PMID: 31487681.

Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability.
J Natl Cancer Inst 2004;96:261–8

FAP

Surgical management of the duodenal manifestations of familial adenomatous polyposis

Guidelines for the clinical management of familial adenomatous polyposis (FAP)

Contact Information

European Hereditary Tumour Group
Secretary:
Gabriele Sponholz

+49 (0)160 84 59 502
gs007@ehtg.org

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